Diabetic nephropathy is the leading cause of
kidney disease in patients starting renal replacement therapy and affects ∼40% of type 1 and type 2 diabetic patients. It increases the
risk of death, mainly from cardiovascular causes, and is defined by increased urinary
albumin excretion (UAE) in the absence of other renal diseases. Diabetic
nephropathy is categorized into stages: microalbuminuria (UAE >20 μg/min and
≤199 μg/min) and macroalbuminuria (UAE ≥200 μg/min). Hyperglycemia, increased
blood pressure levels, and genetic predisposition are the main risk factors for
the development of diabetic nephropathy. Elevated serum lipids, smoking habits,
and the amount and origin of dietary protein also seem to play a role as risk
factors. Screening for microalbuminuria should be performed yearly, starting 5
years after diagnosis in type 1 diabetes or earlier in the presence of puberty
or poor metabolic control. In patients with type 2 diabetes, screening should
be performed at diagnosis and yearly thereafter. Patients with micro- and
macroalbuminuria should undergo an evaluation regarding the presence of
comorbid associations, especially retinopathy and macrovascular disease.
Achieving the best metabolic control (A1c <7%), treating hypertension
(<130/80 mmHg or <125/75 mmHg if proteinuria >1.0 g/24 h and increased
serum creatinine), using drugs with blockade effect on the
renin-angiotensin-aldosterone system, and treating dyslipidemia (LDL cholesterol
<100 mg/dl) are effective strategies for preventing the development of
microalbuminuria, in delaying the progression to more advanced stages of
nephropathy and in reducing cardiovascular mortality in patients with type 1
and type 2 diabetes.
2014年6月27日星期五
2014年6月25日星期三
The Risks and Complications of Uncontrolled Diabetes
If not controlled, diabetes can put you at risk for a host of
complications that can affect nearly every organ in the body. They include:
·
The
eyes
·
The
kidneys
·
The
nerves
·
The
gums and teeth
Heart Disease, Blood
Vessel Disease, and Diabetes
Heart
disease and blood vessel
disease are the biggest complications that people with uncontrolled diabetes
face. In 2004, approximately 68% of diabetes-related death certificates among
people aged 65 years or older were related to heart disease, with stroke being
noted in 16% of death certificates. Diabetes can also cause poor blood
flow in the legs and feet (peripheral artery disease).
Adults with diabetes have heart disease death rates about
two to four times higher than adults without diabetes.The risk for stroke is
two to four times higher .
Many
studies show that controlling diabetes can prevent or stop the progression of
heart and blood vessel disease.
Blood
vessel damage or nerve damage (see below) may also lead to foot problems that can
lead to amputations. More than 60% of leg and foot amputations not related to
an injury are due to diabetes.
Continue
reading below...
Diabetes and the Eyes
Diabetes
is the leading cause of new blindness in the
U.S. in adults ages 20-74. It can cause a number of eye problems,
some of which can lead to blindness if not addressed. The eye disorders
include:
·
Glaucoma
·
Cataracts
·
Diabetic
retinopathy
Studies
show that regular eye exams and timely treatment of diabetes-related eye
problems could prevent up to 90% of diabetes-related blindness.
Kidney Disease and
Diabetes
Diabetes is the leading cause of kidney failure in adults
in the U.S., accounting for 44% of new cases in 2008.Drugs that lower blood pressure (even if you don't have high blood pressure) can lower risk of kidney failure by 33%.
Diabetes and Your Nerves
Over
time, high blood sugar levels can harm the nerves. This can lead to loss of sensation
or feeling (usually starting in the toes) or pain and burning of the feet. Approximately 60-70% of people with diabetes have
some form of nerve damage.
Diabetes-related
nerve damage can also cause pain in the legs, arms, and hands, and can cause
problems with digestion, going to the bathroom, or having sex.
Diabetes and Your Teeth
People
with diabetes are at high risk for gum disease. Keeping your diabetes under control, seeing your
dentist regularly, and taking good daily care of your teeth can prevent gum
disease and tooth loss.
The Cause of Diabetes
Complications
Diabetes
complications are caused by damage to the blood vessels, nerves, or both.
Symptoms of Diabetes
Complications
Symptoms
vary depending on the diabetes complication that you have. You may have:
·
No
symptoms if you have heart disease or atherosclerosis of a large blood vessel, unless you have a heart attack or stoke. Disease of the large blood vessels in
your legs may cause problems with blood circulation, leading to leg cramps,
changes in skin color, and decreased sensation.
·
No
symptoms if you have early diabetes-related kidney disease. Swelling of the
legs and feet occur in more advanced stages of kidney failure.
·
Tingling,
numbness, burning, or shooting or stabbing pain in the feet, hands, or other
parts of your body, if the nerves are affected by diabetes (peripheral diabetic neuropathy). If the nerves that control internal organs are damaged
(autonomic neuropathy), you may have sexual problems, digestive problems (a
condition called gastroparesis); difficulty sensing when your bladder is
full; dizziness, fainting, or difficulty knowing when your blood sugar
is low.
Prevention of Diabetes Complications
When
diabetes complications are found early, you might only have to take medication
to prevent progression of the disease. Only minor lifestyle changes may be
necessary. For example, if you have early diabetic nephropathy, you can take
medication to prevent further damage. Early treatment for a complication and
keeping your blood sugar levels within a safe range can help slow the
progression of your complication and may prevent other complications from
developing.
Treatment of Diabetes Complications
Treatment
of diabetes complications focuses on slowing the progression of the damage.
That may include medication, surgery, or other treatment options.
But
the most important treatment to slow the progression of diabetes complications
is to keep your blood sugar levels tightly in control and to treat high blood
pressure and high
cholesterol.
订阅:
博文 (Atom)
